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Somatic genomics as a discovery engine for biomedicine

When tumour cells invade, macrophages are polarized into the M1 or M2 phenotypes, however, over time, the increased accumulation of TME lactate levels increases lactate levels and histone lactation levels in M1 macrophages, which induces the expressions of M2-like phenotypes (Arg1 and VEGFA)

Multifactorial diseases In his work at Tune Therapeutics, Cosgrove uses epigenome editing technology to target complex diseases, in which the expression of several different genes must be tuned to normal levels