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Normally, both SAMe and glutathione are made from the amino acid methionine in our diet, via homocysteine

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Although these trigger sites presumably afford greater affinity to the Argonaute (AGO)miRNA complex owing to pairing to the miRNA 3 region 17 , this increased affinity is insufficient to explain the selectivity of the target-directed miRNA degradation (TDMD) machinery for the vastly outnumbered trigger-bound complexes