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However, it is important to note that the vast majority of this data comes from animal models, and human clinical trial data remains limited

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The Nasal Spray Nuance: More Than Just Temperature Creating a nasal spray introduces even more variables that make proper storage critical

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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)