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Description

Bidirectional Regulation between NDRG1 and GSK3 Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in Glioblastoma

DOI: Published: Publisher Name: Humana, New York, NY Print ISBN: 978-1-0716-2344-2 Online ISBN: 978-1-0716-2345-9 eBook Packages: Springer Protocols

However, this relatively simple model has now been challenged in light of recent data from genome-wide analyses of human tumors, genetically engineered mouse models of cancer, and systems biology approaches that reveal unique and sometimes opposing HIFa activities in both normal physiology and disease