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Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase

Systemic inflammatory mediators are effective biomarkers for predicting adverse outcomes in Clostridioides difficile infection

Zger S, Svedlund J, Holgers K-M

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The same researchers studied the occurrence of autophagy and found that arsenic trioxide upregulated mitochondrial cell death protein BNIP3, thereby opening mitochondrial permeability transition pores and destroying the integrity of the mitochondrial membrane [19].An inhibitor of caspase-3 could not prevent cell death induced by arsenic trioxide, but apoptosis occurred when the autophagy inhibitor bafilomycin A1 was used in combination with arsenic trioxide [20]