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Chancelerie des universits de Paris (Legs Poix), Fondation pour la Recherche Mdicale (FRM)

Retinol accelerates cell turnover and has some collagen-stimulating effects, but it can cause irritation, dryness, and photosensitivity making it less ideal for patients with sensitive skin or those in sun-intensive environments like Ponte Vedra Beach

Besides the increase of this oxysterol, which acts as a precursor of CDCA, the primary BA synthesized in the mitochondrial alternative pathway, STARD1-mediated cholesterol trafficking results in accumulation of cholesterol in the MIM, which results in far-reaching consequences, such as disruption of mitochondrial physical properties, leading to decreased membrane fluidity that impairs mitochondrial antioxidant defense, illustrated by the depletion of mitochondrial glutathione (GSH) [131135]

Iron accumulation and the dysregulation of proteins involved in iron homeostasis have been demonstrated in the retinas of AMD patients [15,16,17,18,19,20]