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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

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It does show that the idea of inhaled glutathione has a real biologic and clinical basis

Also, regulatory and agency documentation should be cited directly in IRB submissions

HA also contributes directly to cartilage protection through its high molecular weight, which guards chondrocytes against oxidative stress caused by reactive oxygen species