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Two days later, villi were isolated from the proximal small intestine as previously described 5,45,46 , and embedded in collagen or Matrigel matrices and cultured with the same medium (Fig

Lead-induced toxicity is manifested by loss of kidney function accompanied by altered fluid homeostasis as a result of a decreased glomerular filtration rate and activation of the reninangiotensin system, promoting fluid retention with various pathological consequences, such as peripheral edema and pulmonary edema

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Notably, they observed a significant increase in the acetylation of the H3K18 histone mark and a decrease in the H3K4me2 mark on nucleosomes near transcription start sites

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