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In vivo and vitro experiments revealed that hypoxic stress enhances yes-associated protein (YAP) binding to HIF-1, activating GLUT1 transcription thus promotes glycolysis in PTC [177]

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Interestingly, ROS also inhibit SR calcium ATPase (SERCA) activity (146, 414), and paradoxically, reductive stress also inhibits SERCA function by reducing sulfhydryl groups on SERCA that are required for ATP hydrolysis (92)

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