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Methionine is an essential proteinogenic amino acid and also the precursor of S-adenosylmethionine (SAM), the universal reactive methyl donor in biochemical reactions (Figure 3)

Fatigue Autoimmune-related fatigue is among the most debilitating and difficult-to-treat symptoms patients face

HHcy may result from a deficiency in essential dietary components, such as vitamin B 6 , B 12 , and folate

In fact, less than a quarter of the variation in MMA levels is explained by vitamin B12 levels, eGFR, age, and sex, indicating that a large part of the variation in MMA levels is attributable to other factors (eg, catabolism, dietary components, or gut microbial production)