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105 Compared with wild-type controls, mice deficient in the 5-LOX metabolite LTB4 receptor and BLT1 exhibited significantly improved hepatic lipid deposition and insulin resistance in the HFD-induced NAFLD mouse model

The dramatic clinical effect of COL5A1 haploinsufficiency is surprising, given that collagen V is a quite minor constituent of collagen in skin, tendon, and ligament, but the clinical phenotype clearly supports an important function for collagen V in the maintenance of biomechanical integrity of collagenous matrix

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