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Mortality rates among DFU patients escalate sharply, reaching 13.1% at 1 year, 49.1% at 5 years, and 76.9% at 10 years post-diagnosis 5

Clinical evidence remains limited and outcomes vary by patient

Also, it is a key enzyme involved in one of the central pathways of one-carbon metabolism and is essential for various cellular functions, including DNA synthesis, methylation reactions, and the production of important molecules such as SAM

The accepted mechanism of this catalytic reaction (derived from many years of biochemical and modelling studies) envisages a two-step process shown in Equations 2 and 3 [Alfonso-Prieto, 2008]

Iron's role in neurodegenerative disorders might extend beyond Parkinson's disease, impacting diseases like multiple sclerosis (MS), dementia, chronic headaches, and conditions like leaky gut syndrome