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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

MRM transitions for SAM (RT: 6.1 min) were 399298 (4 V), 399250 (12 V), 39997 (32 V) and 399136 (24 V) for M + 0, and 400299 (4 V), 400251 (12 V), 40097 (32 V), 400137 (24 V), 400250 (12 V) and 400136 (24 V) for M + 1

The major phase of enzymatic detoxification in many species is the conjugation of activated xenobiotics to reduced glutathione (GSH) catalyzed by the glutathione- S -transferase (GST)

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Copper amine oxidase 1 (CuAO1) is another candidate enzyme involved in NO synthesis (Wimalasekera et al., 2011)