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CB1 receptors, located mainly in the central nervous system, suppress excitatory neurotransmitter release at presynaptic terminals, while CB2 receptors in immune and peripheral tissues regulate inflammatory signaling and cytokine production [74,75,76]

USA 119 , e2113290119 (2022)

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Punicalagin regulates signaling pathways in inflammation-associated chronic diseases

In all three of these aforementioned clinical treatment studies performed by the authors, biomarkers of redox and methylation metabolism were measured