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In contrast, RIPK3 kinase inhibitor GSK872 44 , ferroptosis inhibitor Fer-1 45 , pyroptosis inhibitor disulfiram 46 and MLKL inhibitor GW806742X 47 had no impact on TNF/CHX-induced cell death in HK2-deficient cells (Supplementary Fig

Furthermore, we demonstrated that the inhibition of IGF2BP3 leads to the destabilization of CACNA1A, thereby promoting anticancer effects through the facilitation of calcium (Ca 2+ )-regulated ferroptosis

The study received approval from the hospitals ethics committee, and all participants provided written informed consent

Immunofluorescence results showed that HK2 was highly expressed in the AKT/N-Ras HCC model (Supplementary Fig

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