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In addition, riboflavin and pyridoxine, which requires riboflavin for its activation, have been shown to have intrinsic neuroprotective properties against glutamate excitotoxicity

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LY46 exhibited dynamic and coordinated upregulation of multiple stress-responsive TF families, whereas HGN displayed a more subdued and limited transcriptional response

Pharmaceutics 14:1326

Consequently, they cause multiple complications including hypertension, which is characterized by an increase in blood pressure on the vessel walls and by the increase in their resistance to the cardiac pump (135)