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Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies

245,246 By modifying specific sites on nucleobases, the stability and affinity of nucleic acids can be greatly improved

doi: 10.1016/S0092-8674(00)81750-X 61 GuoF.PanF.ZhangW.LiuT.ZuberF.ZhangX.et al

Key Takeaways Glutamine is a primary fuel source for intestinal cells, vital for maintaining a healthy gut barrier

And receptor-editing-like events occur in other contexts, such as in the thymus, where intact antigen receptors can be edited as a result of there being insufficient signal strength for the cell to be positively selected, a process that is normally required to terminate recombination at the locus that encodes the -chain of the T-cell receptor (TCR)