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The effects of child formula toothpastes on enamel caries using two in vitro pH-cycling models

Drug Deliv 30:2174206

In DBA/2 J mice, increased levels of mitochondria with altered morphology and diminished capacity for oxidative metabolism, together with decreased LAMP1, despite increased numbers of autophagosomes, led to the belief that these mice had impaired mitophagy (Coughlin et al., 2015)

This was noted with peripheral nerve injury (Tudor et al., 2010), various encephalopathies (Vukojevic et al., 2020), and spinal cord injury (Tohyama et al., 2004

FOXO1 activation leads to the upregulation of both C/EBP and ATF4, which then coordinate to enhance the transcription of target genes, including ChaC1