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Abrupt discontinuation of corticosteroids may lead to disease exacerbation

Among the key causative agents, anthracyclines, such as doxorubicin (DOX), are particularly notable, as the severe cardiac damage they inducecharacterized by ventricular dilatation, interstitial fibrosis, and progression to HFsignificantly limits their clinical utility [73]

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Its approval was supported by the Phase III ARCADIA clinical trial program, which included more than 1,700 patients and found that Nemluvio given every four weeks led to significant improvements in skin clearance versus placebo