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Phase 1 study to evaluate the effects of rifampin on pharmacokinetics of pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors

The shift from downregulation to upregulation at later stages can be explained by cells trying to compensate and rescue the ferroptotic cell death by increasing the expression of antioxidant proteins and enzymes

In a study on pancreatic cancer, CB-839 was utilized to target glutamine metabolism, resulting in the effective inhibition of cell growth in pancreatic cancer cells [227]

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In the early phase (1 h post-administration), NR is rapidly absorbed by the small intestine and enters salvage 127