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Oxidative stress and the pathogenesis of cholestasis

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These bioactive molecules specifically target and inhibit the cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) enzymatic pathways

Wong, T.E

1 Introduction Kidney disease is a major global non-communicable disease (NCD), with a global prevalence exceeding 10% [affecting ~850 million people when including acute kidney injury (AKI), kidney failure, and dialysis/transplant recipients] ( Cell death is a finely regulated process that occurs through various molecular pathways ( Recent studies have confirmed that the kidney is particularly susceptible to redox imbalance, and ferroptosis plays a significant role in the pathophysiology of various kidney diseases, emerging as a new research hotspot in the field of renal fibrosis ( Figure 1