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Because OSAS causes repeated cycles of hypoxia and re-oxygenation that resemble ischemia-reperfusion, the production of reactive oxygen species (ROS) can result from excessive mitochondrial reduction during hypoxia [6]

These areas might feel different tooalmost like velvet or have a bumpy texture

PMID: 39252968 iScienceHypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE

doi: 10.1016/j.nicl.2020.102403 [DOI] [PMC free article] [PubMed] [Google Scholar] 146.Hai T, Swansburg R, Kahl CK, Frank H, Stone K, Lemay J-F, et al

The tissue interstitial fluid and macromolecules enter the lymphatic system through initial lymphatic vessels to form lymph and subsequently drain to the collecting lymphatic vessels and LNs