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In experimental models, silymarin treatment has been linked to reduced lipid peroxidation and improved liver histology, showcasing its capacity to protect against oxidative stress and promote cellular stability

The increased water solubility can be mediated also via conjugation reactions where glutathione serves as one of the substrates

J Pharmacol Exp Ther 285(2):608618 Chen Z, Putt DA, Lash LH (2000) Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport