liposomal glutathione encapsulation in phospholipid vesicles Liposomes: structure, composition, types, and clinical applications: Heliyon Effect of phospholipid head group

Protein binding is high in hemoglobin, low in myoglobin, enzymes, and iron-transporting proteins, and low in ferritin or hemosiderin

Dalbeni A, Bevilacqua M, Teani I, Normelli I, Mazzaferri F, Chiarioni G (2021) Excessive vitamin B12 and poor outcome in COVID-19 pneumonia

It provides hydration and acts as a carrier to deliver the vitamins and minerals into the bloodstream

While the applicant states that SPEVIGO will be the first GPP treatment targeting the IL-36 pathway, we note that per the applicant, other treatments are available and we therefore question whether placebo is the most appropriate comparator

In editing GSH, frequency-selective pulses are applied to the GSH signals at 4.56 ppm in order to resolve the GSH signal at 2.95 ppm in the difference spectrum