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The liver is especially glutathione-dependent

Kennedy, Jay C

PtMo-Au metalloenzymes regulated tumor microenvironment for enhanced sonodynamic/chemodynamic/starvation synergistic therapy

91 PerisicT.HolsboerF.ReinT.ZschockeJ

While nanocarriers with smaller sized increased the tumor penetration to some degree 43 , the efficiency was limited as they still needed to transverse the gradient of tenacious interstitial fluid pressure through a densely stuffed paracellular matrix 28