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10.3390/ijms24119520 9

Unlike SIRT5, low expression of SIRT3 leads to increased acetylation and phosphorylation of PDHE1, reduced PDHase activity, and enhanced glycolysis [53]

In ovalbumin-induced mouse asthma models, L-theanine treatment could reduce the transport of inflammatory cells to bronchoalveolar lavage fluid (BALF) and inhibit the infiltration of inflammatory cells via blocking the activation of NF-B pathway and its downstream production of ROS, monocyte chemoattractant protein-1 (MCP-1), IL-4, IL-5, IL-13, TNF-, and interferon (IFN)- in BALF (35)