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Although first slight improvements were shown for pathology-targeting antibody therapy, there is a lack of efficient disease-modifying treatment options due to incomplete knowledge of the pathophysiology and the challenges to overcome the bloodbrain barrier

Central to this approach are dose modification protocols guided by the Common Terminology Criteria for Adverse Events (CTCAE), which provide standardized thresholds for adjusting or withholding treatment based on toxicity grade

5J), similar to UNC10088 (Fig

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