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Cell 149(5):10601072 Yu P, Zhang X, Liu N, Tang L, Peng C, Chen X (2021) Pyroptosis: mechanisms and diseases

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In fact, the GPx4 protein itself possesses a number of cysteine residues on its protein surface, which have been implicated in its ability to form extensive enzymatically inactive protein polymers (Scheerer et al., 2007)

For example, HF individuals with reduced ejection fraction are generally advised against participating in competitive sports, while those with HF and preserved ejection fraction, classified as low-risk, may engage in certain competitive activities

doi: 10.1080/09712119.2015.1091339 109