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NNMT inhibitors display high membrane permeability Compounds spanning ~100-fold IC 50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold[17] to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

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Renal response was also more likely to be durable (lasting 6 months) in the isatuximab-Kd group [54, 64]