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This is fundamentally different from a systemic allergic reaction, which involves the entire immune system and can be dangerous

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The fourth man developed a reversible acute encephalopathy with headache, nausea, vomiting, lethargy, recurrent motor seizures, agitation, and a diffusely slow electroencephalogram (Gross et al., 1979)

Thus, the anti-CD3 antibody effector can be used to enhance an immune response against the anti-ALPL2 targeted cell

Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism