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When stored at -20C, the active ingredients will remain effective for at least 2 months, but the integrity of the liposomes may be damaged when frozen for more than 2 months

Maktabi M, Chamani M, Asemi Z

Aging Cell 14 (5), 887895

Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor upregulating the antioxidant response element (ARE)-mediated expression of antioxidant and detoxifying enzymes, and the Nrf2-antioxidant pathway is critical in host defense against acute lung injury (ALI) 24

Sebum contributes to inflammatory acne lesions and non-inflamed comedones in the form of blackheads or whiteheads