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To date, more than 120 different pathogenic variants of citrin have been reported in the literature worldwide (reviewed in [8], with additional ones in Table 1) and 168 in the Human Gene Mutation Database (HGMD), but the number of identified variants continues to grow with an increasing number of diagnoses each year

Additionally, It is already known that iron accumulates in the body and leads to the abnormal formation of A and neurofibrillary tangles (NFTs), resulting in A plaque misfolding (Yan and Zhang, 2019)

(December 1980)

The concentration of 8-OHdG was observed to be significantly lower for the test cats compared with the control group at week 8 (difference 07, 95 % CI 06, 09 nG/ml

In specific microenvironments, they may even stimulate lymphocyte proliferation (Nikoo et al., 2012)