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doi: 10.2337/db13-0213 65 HotamisligilGS

Gao et al., 2009, 2010)

Aires) 75(5):297302 Funding NA

The pharmacodynamic action of curcumin is dose-dependent, typically requiring higher concentrations to achieve therapeutic efficacy

If a drug is taken into the gastrointestinal tract (GI tract), where it enters the hepatic portal system through the portal vein, it becomes well-metabolized and is said to show the first pass effect