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Most therapeutic interventions remain in preclinical development, with clinical translation hindered by two key barriers: The lack of validated biomarkers for patient stratification and incomplete elucidation of synergistic combination mechanisms

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HO-1, commonly referred to as the 32 kDa heat shock protein, is encoded by the HMOX1 gene, which is localized to human chromosome 22q13.1 and has a molecular weight of 32,800 Da (Kutty et al., 1994)

Moreover, the application of AI/ML as well as xAI to move beyond the limitations of black-box data-driven models is an accelerating trend, not only in biomedical fields 57,58 such as drug and cancer diagnostics but also emerging in bioprocess modeling 59

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