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Sleep is often disrupted by pain, and many patients have other sleep disorders, such as restless legs syndrome and sleep apnea

Tumor cells then utilize lactate and pyruvate secreted by CAFs to sustain increased proliferation

& Hartley, R

Natarajan V

In a recent clinical trial, more than half of CRPC patients showed a prostate-specific antigen (PSA) response when treated with a combination of curcumin and docetaxel