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The combination of three genes, CDO1 (cysteine dioxygenase type 1), HOXA9 (homeobox A9), and TAC1 (tachykinin, precursor 1) has shown great promise in both the early diagnosis and staging of NSCLC (Wrangle et al., 2014)

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1 Introduction The tumor microenvironment (TME) is a complex and evolving entity The composition of TME varies depending on the type of tumor, but its hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix (ECM) ( + macrophages facilitate ECM accumulation through ligand-receptor interactions, thereby influencing the efficacy of immunotherapy for liver cancer ( In 2020, primary liver cancer emerged as the sixth most prevalent cancer globally and the third most fatal ( This review aims to investigate the metabolic interactions between cancerous and non-cancerous cells within the microenvironment of liver cancer

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Protoplasma 251:169176 Xiang C, Oliver DJ (1999) Glutathione and its central role in mitigating plant stress