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Cardiac effects of acute administration of a protonophore in a rat model

Strate, MD, MPH, FACG, University of Washington School of Medicine, Seattle, WA Updated 2016 John DeBanto, MD , Glendale, CA Updated August 2022 Ann Flynn, MD, FACG, University of Utah Health, Salt Lake City, UT - Updated April 2025

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Because aberrations in the PI3K/AKT/mTORC1 pathway are common in PDAC and TNBC [55, 56], it is likely that hyperactivated mTORC1 in these cancers upregulates ERO1 expression and then promotes tumor progression