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Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer persister cells 2,3,4

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ATF4 transcription plays a key role in maintaining cellular homeostasis, thereby promoting cellular adaptation

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In fact, in 2006, the Centers for Disease Control reported that the average American has 116 out of 148 synthetic compounds in their body

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TC2N has been demonstrated to activate the Wnt signalling pathway, thus promoting the invasive metastasis of HCC cells

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Front Pharmacol (2017) 8:296

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