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These findings collectively deepen our understanding of the genetic interplay between TB and DM, emphasizing the need for integrative approaches that consider genetic, metabolic, and environmental factors in addressing TB-DM comorbidity

Scientific data and sources Research summary Level of evidence Preliminary Number of included studies: 42 16 studies 10 studies 9 studies 4 studies 2 studies 1 study Final comment: Epitalon and thymulin are peptides with promising neuroprotective, immunomodulatory, and anti-cancer potential, but most available data come from animal studies and in vitro models

Br J Haematol (2022) 198(2):221

This impairment alters downstream AKT1 effectors including GSK3, FOXO, and mTOR, which are implicated in increased susceptibility to oxidative stress and neuronal death

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