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In cell-based assays, ARA-290 is applied to cultured neuronal cell lines, primary Schwann cells, and pancreatic islet preparations to study receptor binding kinetics and intracellular signaling responses including STAT3 and NF-kB pathway modulation

It is difficult to judge for sure whether the early drastic decrease in Plp- and Mog- positive cells implies a drastic death/loss of the mature OLs or just an extreme-down regulation of the expression of these myelin-associated genes by the OLs while they themselves are still alive

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Interestingly, host T cell immune response was needed to inhibit HO-1 by SnPPIX, and SnPPIX failed to reduce bacterial growth and activity of Mtb HO-1 enzyme in broth culture (192)

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