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Caution should be exercised in patients with a history of heart disease, diabetes, hypertension, or kidney problems

Growth hormone secretagogues demonstrate a bell-shaped dose-response curve, meaning that beyond a certain threshold, increasing the dose yields no additional benefit and may reduce receptor sensitivity. Smith et al., Peptides Taking too much Ipamorelin can lead to diminished returns , or worse, GH resistance , where your body adapts and no longer responds

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