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unknown long-term human safety profile

Or are there some specific ingredients that must be avoided and not necessarily all chemical sunscreens

Signal Transduct Target Ther 7(1):48 Wang C, Shao S, Li N, Zhang Z, Zhang H, Liu B (2023) Advances in Alzheimers disease-associated A therapy based on peptide

Octocrylene's safety profile is generally quite good, though a review study in Contact Dermatitis reports an "increasing number of patients with photo contact allergy to octocrylene." Mainly adults with ketoprofen-sensitivity and children with sensitive skin are affected, so if you have a small kid, it is probably better to use octocrylene-free sunscreens