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It is also the first medication approved for the treatment of idiopathic hypersomnia in adults

In this sense, both academia and the pharmaceutical industry have been trying to develop innovative synthetic strategies with a view to speeding up the PROTACs discovery

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First, according to the simulations, GS can react with a GSH molecule

In addition, this treatment also downregulated Bcl-2, MDR-1, survivin, vimentin, CXCR4, IL-10, and PD-L1, while increasing the expression of FADD, APAF-1, caspase-3, IFN-, and E-cadherin in malignant cells [182]