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Description

Headache represents another occasionally reported effect, potentially related to the peptide's vasodilatory properties

The main signaling cascade for local translation at spines requires glutamate binding to metabotropic glutamate receptors (mGluR), which triggers protein-synthesis-dependent forms of spine plasticity by activating extracellular signal-regulated kinase (ERK) or mammalian target of rapamycin (mTOR) pathways (Ebert and Greenberg, 2013)