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However, Humans are poor subjects for these studies because of heterogeneous genetic backgrounds, low reproductive rate, generation times far too important for experimental studies, wide variations in gene expression, subject to strong environmental variations and experimentations on humans are unethical

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Because glutamine metabolism also supports cancer stem cell programs through pathways such as mTOR and Notch signaling, pharmacological or genetic GLS inhibition can reduce stemness markers, deplete ALDH-positive cancer stem-like cells, and enhance radiosensitivity in experimental models (Pschel et al., 2021)

Leticia Prates Roma acknowledges funding from the DFG in the framework of the TRR219, project number 322900939