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Moreover, most of these studies are based on animal experiments and lack validation in large-scale, long-term clinical studies

30 DineshY.OlgaB.YanJ.EricG

26(1): 57.10.1186/s40360-025-00900-8 (2025)

Further experiments revealed that hydrogen-induced Nrf2 can directly bind to NF-B p65, interfering with its DNA-binding ability to pro-inflammatory gene promoters while also suppressing the release of inflammatory mediators such as HMGB1 and TNF-, thereby truncating the positive feedback loop of IKK